Selected article for: "cancer cell and cell proliferation"
Author: Nila Roy Choudhury; Gregory Heikel; Maryia Trubitsyna; Peter Kubik; Jakub Stanislaw Nowak; Shaun Webb; Sander Granneman; Christos Spanos; Juri Rappsilber; Alfredo Castello; Gracjan Michlewski
Title: RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
  • Document date: 2017_10_9
    • ID: ifla4aix_61
    Snippet: Consequently, TRIM25 knockout mice present significantly underdeveloped uteri (Orimo et al., 1995; Orimo et al., 1999) . Furthermore, TRIM25 plays a role in promoting proliferation of many cancer cell types, often in association with the estrogen response (Ikeda et al., 2000; Suzuki et al., 2005; Thomson et al., 2001; Urano et al., 2002) . Recently, TRIM25 has been shown to be a master regulator of breast cancer metastasis (Walsh et al., 2017) . .....
    Document: Consequently, TRIM25 knockout mice present significantly underdeveloped uteri (Orimo et al., 1995; Orimo et al., 1999) . Furthermore, TRIM25 plays a role in promoting proliferation of many cancer cell types, often in association with the estrogen response (Ikeda et al., 2000; Suzuki et al., 2005; Thomson et al., 2001; Urano et al., 2002) . Recently, TRIM25 has been shown to be a master regulator of breast cancer metastasis (Walsh et al., 2017) . Additionally, TRIM25 is known for its role in the Retinoic Acid-Inducible Gene 1 (RIG-I)-mediated interferon pathway (Ozato et al., 2008; Versteeg et al., 2013) . Upon detection of viral RNAs with 5'ppp-RNA, RIG-I activates a signaling cascade that results in phosphorylation-All rights reserved. No reuse allowed without permission.

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