Author: Tsukada, Akinari; Suzuki, Manabu; Kishino, Yuya; Misumi, Kento; Igari, Toru; Nakajima, Noriko; Sato, Yuko; Suzuki, Tadaki; Katsuno, Takashi; Kusaba, Yusaku; Tsujimoto, Yoshie; Sakamoto, Keita; Hashimoto, Masao; Terada, Junko; Takasaki, Jin; Izumi, Shinyu; Hojo, Masayuki; Sugiyama, Haruhito
Title: A Kidney Transplant Patient Who Died of COVID-19-associated Severe Acute Respiratory Distress Syndrome Cord-id: q50ew3lq Document date: 2021_5_29
ID: q50ew3lq
Snippet: We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few severe acute respiratory syndr
Document: We herein report a 67-year-old kidney transplant patient who died of COVID-19. He was treated with hydroxychloroquine and azithromycin and received mechanical ventilation that temporarily improved his respiratory status. Despite our efforts, however, he later developed respiratory failure and died 43 days after the disease onset. The autopsy revealed prominent organization of alveoli and alveolar ducts, with a massive accumulation of macrophages in the lungs. A few severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen-positive cells were detected in the lung, suggesting delayed virus clearance owing to his long-term immunosuppressed state, leading to constant lung damage and ultimately respiratory failure.
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