Author: Adriaan H. de Wilde; A. Linda Boomaars-van der Zanden; Anja W. M. de Jong; Montserrat Barcéna; Eric J. Snijder; Clara C. Posthuma
Title: Inhibition of arterivirus RNA synthesis by cyclophilin inhibitors is counteracted by mutations in replicase transmembrane subunits Document date: 2019_3_24
ID: l5n30kbm_14
Snippet: CsA-1 to -3 viruses, which each carried multiple substitutions. Therefore, we also engineered mutant 284 viruses with genome sequences identical to the consensus sequence of these three CsA-resistant virus 285 lineages. For lineage CsA-1, which contained a mix of Q (wt) and R (mutant) at residue 21 of nsp5, 286.....
Document: CsA-1 to -3 viruses, which each carried multiple substitutions. Therefore, we also engineered mutant 284 viruses with genome sequences identical to the consensus sequence of these three CsA-resistant virus 285 lineages. For lineage CsA-1, which contained a mix of Q (wt) and R (mutant) at residue 21 of nsp5, 286
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