Selected article for: "cov sequence and RBM sequence"
Author: Chunyun Sun; Long Chen; Ji Yang; Chunxia Luo; Yanjing Zhang; Jing Li; Jiahui Yang; Jie Zhang; Liangzhi Xie
Title: SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development
  • Document date: 2020_2_20
    • ID: nhq0oq8y_30
    Snippet: As suggested by the SARS-CoV and SARS-CoV-2 RBD sequence alignment analysis (Figure 1A) , the 50% RBM sequence homology is much less than the 73.7% RBD sequence homology. Structure similarity analysis confirms the presence of significant local structure differences in the RBM regions, while the rest of the RBD regions have significantly higher similarities (Figure 4) . Moreover, three glycosylation sites in SARS-CoV RBD (i.e. N318, N330, and N357.....
    Document: As suggested by the SARS-CoV and SARS-CoV-2 RBD sequence alignment analysis (Figure 1A) , the 50% RBM sequence homology is much less than the 73.7% RBD sequence homology. Structure similarity analysis confirms the presence of significant local structure differences in the RBM regions, while the rest of the RBD regions have significantly higher similarities (Figure 4) . Moreover, three glycosylation sites in SARS-CoV RBD (i.e. N318, N330, and N357) 32 was conserved, although one of the glycosylation sites, N357, may not be glycosylated in the corresponding residue of SARS-CoV-2 as predicted by NetNGlyc 33 .

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