Author: Chunyun Sun; Long Chen; Ji Yang; Chunxia Luo; Yanjing Zhang; Jing Li; Jiahui Yang; Jie Zhang; Liangzhi Xie
Title: SARS-CoV-2 and SARS-CoV Spike-RBD Structure and Receptor Binding Comparison and Potential Implications on Neutralizing Antibody and Vaccine Development Document date: 2020_2_20
ID: nhq0oq8y_39
Snippet: We then screened non-ACE2-blocking antibodies raised from SARS-CoV RBD for neutralizing activities. Three such monoclonal antibodies were identified. Although, binding affinities to SARS-CoV S1 protein was significantly lower with EC 50 between 55 to 224 μg/mL as compared to 16 to 42 μg/mL EC 50 for the four ACE2-blocking nAbs, significant cross-binding activities to SARS-CoV-2 S1 protein and modest cross-neutralizing activities against SARS-Co.....
Document: We then screened non-ACE2-blocking antibodies raised from SARS-CoV RBD for neutralizing activities. Three such monoclonal antibodies were identified. Although, binding affinities to SARS-CoV S1 protein was significantly lower with EC 50 between 55 to 224 μg/mL as compared to 16 to 42 μg/mL EC 50 for the four ACE2-blocking nAbs, significant cross-binding activities to SARS-CoV-2 S1 protein and modest cross-neutralizing activities against SARS-CoV-2 PSV were detected.
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