Author: Hualong Xiong; Yangtao Wu; Jiali Cao; Ren Yang; Jian Ma; Xiaoyang Qiao; Xiangyang Yao; Baohui Zhang; Yali Zhang; Wangheng Hou; Yang Shi; Jingjing Xu; Liang Zhang; Shaojuan Wang; Baorong Fu; Ting Yang; Shengxiang Ge; Jun Zhang; Quan Yuan; Baoying Huang; Zhiyong Li; Tianying Zhang; Ningshao Xia
Title: Robust neutralization assay based on SARS-CoV-2 S-bearing vesicular stomatitis virus (VSV) pseudovirus and ACE2-overexpressed BHK21 cells Document date: 2020_4_9
ID: fvjh3g7v_20
Snippet: We firstly tested the response of VSVdG-SARS-CoV-2- [16] . It also means this pseudoviruse system can mimic the entry of live virus. This system can be used for high-throughput screening of neutralizing antibodies. As The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.08.026948 doi: bioRxiv preprint shown in Figure 5A and 5B, 35 strains of mouse monoclonal antibody hybridoma culture super.....
Document: We firstly tested the response of VSVdG-SARS-CoV-2- [16] . It also means this pseudoviruse system can mimic the entry of live virus. This system can be used for high-throughput screening of neutralizing antibodies. As The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.08.026948 doi: bioRxiv preprint shown in Figure 5A and 5B, 35 strains of mouse monoclonal antibody hybridoma culture supernatants were evaluated using the pseudovirus system, and 7 of them showed significant neutralization. The IC50 of 7 selected neutralizing antibodies for antiviral activity were also analyzed ( Figure 5C ) using this pseudovirus system.
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