Author: Krishan Mohan Kapoor; Aanandita Kapoor
Title: Role of Chloroquine and Hydroxychloroquine in the Treatment of COVID-19 Infection- A Systematic Literature Review Document date: 2020_3_30
ID: 0lk8eujq_2
Snippet: Chloroquine (CQ) has been used extensively as an antimalarial agent with immunomodulatory effects 1 2 3 . A derivative of CQ, Hydroxychloroquine sulfate (HCQ) was synthesized first in 1946 by adding a hydroxyl group to CQ and is much less toxic than CQ in animal studies 4 . CQ has been used in SARS Coronavirus infection due to its antiviral properties 5 6 . Recently CQ has also been found to have Anti-COVID-19 activity in vitro 7 . For these reas.....
Document: Chloroquine (CQ) has been used extensively as an antimalarial agent with immunomodulatory effects 1 2 3 . A derivative of CQ, Hydroxychloroquine sulfate (HCQ) was synthesized first in 1946 by adding a hydroxyl group to CQ and is much less toxic than CQ in animal studies 4 . CQ has been used in SARS Coronavirus infection due to its antiviral properties 5 6 . Recently CQ has also been found to have Anti-COVID-19 activity in vitro 7 . For these reasons, CQ and HCQ could be the potential drug for treating COVID-19 infection. To date, there is no clinical evidence to support the use of CQ or HCQ for treating SARS-CoV-2 infection though many clinical trials with these drugs are already underway 8 . This study aims to systematically review the available literature for the use of CQ or HCQ in treating COVID-19 infection.
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