Author: Cécilia Hognon; Tom Miclot; Cristina Garcia Iriepa; Antonio Francés-Monerris; Stephanie Grandemange; Alessio Terenzi; Marco Marazzi; Giampaolo Barone; Antonio Monari
Title: Role of RNA Guanine Quadruplexes in Favoring the Dimerization of SARS Unique Domain in Coronaviruses Document date: 2020_4_10
ID: dnppshnv_1_1
Snippet: that RNA may be instrumental in favoring SUD dimerization, due to the negative charge of the RNA backbone hence suggesting the occurrence of electrostatic attraction. This observation may have a highly important biological implication since the dimerization has also been connected to the SUD native function. Tan et al 28 have proposed that the ability of SUD to recognize and bind specific viral and/or host G4 sequences may have implications in re.....
Document: that RNA may be instrumental in favoring SUD dimerization, due to the negative charge of the RNA backbone hence suggesting the occurrence of electrostatic attraction. This observation may have a highly important biological implication since the dimerization has also been connected to the SUD native function. Tan et al 28 have proposed that the ability of SUD to recognize and bind specific viral and/or host G4 sequences may have implications in regulating viral replication and/or hampering the host response to viral infection, as schematized in Figure 1 .
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