Author: Goebel, Scott J; Taylor, Jill; Barr, Bradd C; Kiehn, Timothy E; Castro-Malaspina, Hugo R; Hedvat, Cyrus V; Rush-Wilson, Kim A; Kelly, Cassandra D; Davis, Stephen W; Samsonoff, William A; Hurst, Kelley R; Behr, Melissa J; Masters, Paul S
Title: Isolation of avian paramyxovirus 1 from a patient with a lethal case of pneumonia. Cord-id: ubcm30uu Document date: 2007_1_1
ID: ubcm30uu
Snippet: An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant. A random PCR-based molecular screening method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections. Immunohistochemical analysis confirmed the
Document: An unknown virus was isolated from a lung biopsy sample and multiple other samples from a patient who developed a lethal case of pneumonia following a peripheral blood stem cell transplant. A random PCR-based molecular screening method was used to identify the infectious agent as avian paramyxovirus 1 (APMV-1; a group encompassing Newcastle disease virus), which is a highly contagious poultry pathogen that has only rarely been found in human infections. Immunohistochemical analysis confirmed the presence of APMV-1 antigen in sloughed alveolar cells in lung tissue from autopsy. Sequence from the human isolate showed that it was most closely related to virulent pigeon strains of APMV-1. This is the most completely documented case of a systemic human infection caused by APMV-1 and is the first report of an association between this virus and a fatal disease in a human.
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