Author: Coleman, Gerald L.; Barthold, Stephen W.; Osbaldiston, George W.; Foster, Sumner J.; Jonas, Albert M.
Title: Pathological Changes During Aging in, Barrier-Reared Fischer 344 Male Rats(1) Cord-id: yfdb594k Document date: 1977_5_25
ID: yfdb594k
Snippet: Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease sev
Document: Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease severity with increasing age. Serum total protein and albumin decreased with age, while alpha-1 globulin and cholesterol increased.
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