Author: Seliem, Israa A.; Panda, Siva S.; Girgis, Adel S.; Moatasim, Yassmin; Kandeil, Ahmed; Mostafa, Ahmed; Ali, Mohamed A.; Nossier, Eman S.; Rasslan, Fatma; Srour, Aladdin M; Sakhuja, Rajeev; Ibrahim, Tarek S.; Abdel-samii, Zakaria K.M.; Al-Mahmoudy, Amany M.M.
Title: New quinoline-triazole conjugates: Synthesis, and antiviral properties against SARS-CoV-2 Cord-id: qf4v2uc2 Document date: 2021_6_23
ID: qf4v2uc2
Snippet: At present therapeutic options for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are very limited. We designed and synthesized three sets of small molecules using quinoline scaffolds. A series of quinoline conjugates (10a-l, 11a-c, and 12a-e) by incorporating 1,2,3-triazole were synthesized via a modified microwave-assisted click chemistry technique. Among the synthesized conjugates, 4-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-fluoro-2-(trifluoromethyl)quinoline (10g)
Document: At present therapeutic options for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) are very limited. We designed and synthesized three sets of small molecules using quinoline scaffolds. A series of quinoline conjugates (10a-l, 11a-c, and 12a-e) by incorporating 1,2,3-triazole were synthesized via a modified microwave-assisted click chemistry technique. Among the synthesized conjugates, 4-((1-(2-chlorophenyl)-1H-1,2,3-triazol-4-yl)methoxy)-6-fluoro-2-(trifluoromethyl)quinoline (10g) and 6-fluoro-4-(2-(1-(4-methoxyphenyl)-1H-1,2,3-triazol-4-yl)ethoxy)-2-(trifluoromethyl)quinoline (12c) show high potency against SARS-CoV-2. The selectivity index (SI) of compounds 10g and 12c also indicates the significant efficacy compared to the reference drugs.
Search related documents:
Co phrase search for related documents- Try single phrases listed below for: 1
Co phrase search for related documents, hyperlinks ordered by date