Selected article for: "protein domain and structural domain"
Author: Cláudia Pereira; Rita M. Reis; José B. Gama; Dhanya K. Cheerambathur; Ana X. Carvalho; Reto Gassmann
Title: Self-assembly of the RZZ complex into filaments drives kinetochore expansion in the absence of microtubule attachment
  • Document date: 2018_3_15
    • ID: ajkhpw5f_27
    Snippet: Based on our analysis of C. elegans RZZ, we suggest that human ROD's central role in kinetochore expansion is directly related to its capacity for oligomerization. We envision that filamentous RZZ assemblies form the structural scaffold of the expanded kinetochore domain and function as dynamic recruitment platforms for corona proteins, including SAC components, the motors dynein and CENP-E, and CENP-F. In contrast to the KMN network, protein-pro.....
    Document: Based on our analysis of C. elegans RZZ, we suggest that human ROD's central role in kinetochore expansion is directly related to its capacity for oligomerization. We envision that filamentous RZZ assemblies form the structural scaffold of the expanded kinetochore domain and function as dynamic recruitment platforms for corona proteins, including SAC components, the motors dynein and CENP-E, and CENP-F. In contrast to the KMN network, protein-protein interactions among components in the expanded outer domain are low-affinity and therefore challenging to dissect with biochemical approaches.

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