Author: Wang, Min; Xiong, Zhenzhen; Su, Bin; Wang, Lan; Li, Zhixiong; Yang, Yali; Fang, Jing; Li, Zhe
Title: Repeated ketamine injections in synergy with antidepressants for treating refractory depression: A case showing 6-month improvement. Cord-id: zefaxwpg Document date: 2019_1_1
ID: zefaxwpg
Snippet: WHAT IS KNOWN AND OBJECTIVE Some patients with refractory depression who fail to respond to rapid injection of standard-dose ketamine are injected with high doses, but the safety and efficacy of this practice are unclear. CASE DESCRIPTION A 57-year-old woman with refractory depression whose symptoms did not improve after 20-seconds intravenous injection of 0.5 mg/kg ketamine went into remission following eight, 1-minute intravenous injections of 1 mg/kg ketamine delivered over a 4-week period. B
Document: WHAT IS KNOWN AND OBJECTIVE Some patients with refractory depression who fail to respond to rapid injection of standard-dose ketamine are injected with high doses, but the safety and efficacy of this practice are unclear. CASE DESCRIPTION A 57-year-old woman with refractory depression whose symptoms did not improve after 20-seconds intravenous injection of 0.5 mg/kg ketamine went into remission following eight, 1-minute intravenous injections of 1 mg/kg ketamine delivered over a 4-week period. By 6-month follow-up, no significant adverse events had occurred and cognitive function had improved. WHAT IS NEW AND CONCLUSION High-dose intravenous injections of ketamine may stably improve depressive symptoms and cognitive function in patients with refractory depression who do not respond to rapid intravenous injection of standard-dose ketamine. The high-dose treatment appears to be associated with only mild side effects.
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