Author: Nardacci, Roberta; Colavita, Francesca; Castilletti, Concetta; Lapa, Daniele; Matusali, Giulia; Meschi, Silvia; Del Nonno, Franca; Colombo, Daniele; Capobianchi, Maria Rosaria; Zumla, Alimuddin; Ippolito, Giuseppe; Piacentini, Mauro; Falasca, Laura
Title: Evidences for lipid involvement in SARS-CoV-2 cytopathogenesis Cord-id: yjdu4k9v Document date: 2021_3_12
ID: yjdu4k9v
Snippet: The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-CoV-2 cellular cytopathic effects requires definition. We performed a comparative ultrastructural study of SARS-CoV-1 and SARS-CoV-2 infection in Vero E6 cells and in lungs from deceased COVID-19 patients. SARS-CoV-2 induces rapid death associated with profound ultrastructural changes in Vero cells. Type II pneumocytes in lung tissue showed prominent altered features with numerous vacuoles and swollen mitochond
Document: The pathogenesis of SARS-CoV-2 remains to be completely understood, and detailed SARS-CoV-2 cellular cytopathic effects requires definition. We performed a comparative ultrastructural study of SARS-CoV-1 and SARS-CoV-2 infection in Vero E6 cells and in lungs from deceased COVID-19 patients. SARS-CoV-2 induces rapid death associated with profound ultrastructural changes in Vero cells. Type II pneumocytes in lung tissue showed prominent altered features with numerous vacuoles and swollen mitochondria with presence of abundant lipid droplets. The accumulation of lipids was the most striking finding we observed in SARS-CoV-2 infected cells, both in vitro and in the lungs of patients, suggesting that lipids can be involved in SARS-CoV-2 pathogenesis. Considering that in most cases, COVID-19 patients show alteration of blood cholesterol and lipoprotein homeostasis, our findings highlight a peculiar important topic that can suggest new approaches for pharmacological treatment to contrast the pathogenicity of SARS-CoV-2.
Search related documents:
Co phrase search for related documents- aberrant immune response and lung tissue: 1
- accession number and acute respiratory: 1, 2, 3, 4, 5
- accession number and lung tissue: 1
- acute respiratory and lung sample: 1, 2, 3, 4
- acute respiratory and lung section: 1, 2, 3, 4, 5
- acute respiratory and lung specimen: 1, 2, 3, 4, 5, 6
- acute respiratory and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73, 74
- acute respiratory and lung tissue pcr test: 1
- acute respiratory and lung tissue sample: 1, 2
- acute respiratory and lung type ii pneumocyte: 1, 2
- acute severe pneumonia and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
Co phrase search for related documents, hyperlinks ordered by date