Author: Tokarz, Rafal; Hirschberg, David L; Sameroff, Stephen; Haq, Saddef; Luna, Giannina; Bennett, Andrew J; Silva, Maria; Leguia, Mariana; Kasper, Matthew; Bausch, Daniel G; Lipkin, W Ian
Title: Genomic analysis of two novel human enterovirus C genotypes found in respiratory samples from Peru. Cord-id: ym20a0yn Document date: 2013_1_1
ID: ym20a0yn
Snippet: We report the discovery of two enteroviruses detected in nasopharyngeal samples obtained from subjects with respiratory disease in Peru. Phylogenetic analysis indicated that both viruses belong to a clade within the species Human enterovirus C, which includes the recently characterized human enteroviruses 109 and 104. Members of this clade have undergone significant genomic rearrangement, as indicated by deletions in the hypervariable region of the 5' UTR and the VP1 protein, as well as recombin
Document: We report the discovery of two enteroviruses detected in nasopharyngeal samples obtained from subjects with respiratory disease in Peru. Phylogenetic analysis indicated that both viruses belong to a clade within the species Human enterovirus C, which includes the recently characterized human enteroviruses 109 and 104. Members of this clade have undergone significant genomic rearrangement, as indicated by deletions in the hypervariable region of the 5' UTR and the VP1 protein, as well as recombination within the non-structural genes. Our findings and review of published sequences suggests that several novel human enterovirus C serotypes are currently circulating worldwide.
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