SARS-CoV-2 might manipulate against its host the immunity RNAi/Dicer/Ago system Does mitochondria collapse upon COVID-19 infection?

Claude Pasquier; Alain Robichon

Amazingly the found sequences in our computational search converge to major genes involved in endosome formation, mitochondria and ubiquitine system. The importance of ubiquitin system in innate viral immunity has been largely documented, which concurs to solidify the theoretically computational finding. Putatively dsRNAs, hybrid form with one strand coming from human transcriptome and the other viral RNA might have the unfortunate role to direct the Dicer/ago/RISC defense system against his own host. All way around SARS-CoV-2 might have "stolen" a piece of genetic information from host cells namely a reverse complement segment of an important gene, which in fine might use Dicer as self destruction or self suicide for infected cells. Q-PCR analysis will be required to confirm the hypothesis of down regulation of human transcripts via activation of RNAi pathway directed against the host and triggered by pieces of RNA information arising from SARS-CoV-2.