Nasal Polyposis and Its Association with Cardiac Functions.

Dhiman, Sapna; Dhiman, Abhishek; Azad, Ramesh K; Negi, Prakash C; Lal, Bhushan; Thakur, Jagdeep S

OBJECTIVE The aim of the study was to ascertain the effect of nasal polyposis on cardiac functions. MATERIAL AND METHODS A prospective randomized interventional open-label endpoint-controlled study was conducted in an academic tertiary care hospital. Thirty-one patients with chronic rhinosinusitis with nasal polyposis were enrolled and administered fluticasone furoate nasal spray for 3 weeks before randomly segregation into surgical or medical group. The treatment continued for 3 months in both groups. The SNOT-22 (Sino-Nasal Outcome Test-22) score, polyp grade, and right ventricular and pulmonary arterial functions were recorded in both groups before and after 3 months of the intervention. RESULTS Both groups had significant improvement in SNOT-22 scores after 3 months of intervention. Both groups showed improvement in cardiac functions, but statistical significance was found only in subjects who underwent surgery. CONCLUSION Nasal polyp affects cardiac functions, and this needs further evaluation and research through studies on large samples.