Author: Corey T Watson; Karyn Meltz Steinberg; Tina A Graves-Lindsay; Rene L Warren; Maika Malig; Jacqueline E Schein; Richard K Wilson; Rob Holt; Evan Eichler; Felix Breden
Title: Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity Document date: 2014_7_3
ID: 62gfisc6_20
Snippet: Interestingly, in IGHV, SNP density was higher in regions of segmental duplication compared to regions not covered by SDs, especially true when considering only those regions covered by SDs with >95% sequence identity (Table 2) ; however, this difference was not found to be significant after permuting SD vs. non-SD region assignments and re-assessing SNP densities of 10,000 MCFDR samplings (P > 0.05). SNP density was also increased in segmentally.....
Document: Interestingly, in IGHV, SNP density was higher in regions of segmental duplication compared to regions not covered by SDs, especially true when considering only those regions covered by SDs with >95% sequence identity (Table 2) ; however, this difference was not found to be significant after permuting SD vs. non-SD region assignments and re-assessing SNP densities of 10,000 MCFDR samplings (P > 0.05). SNP density was also increased in segmentally duplicated regions of IGKV with >95% sequence identity compared to regions not covered by SDs, but again, this difference was not significant (P > 0.05).
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