Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection Document date: 2019_5_20
ID: bx49tbui_66
Snippet: We validated severity-associated gene expression changes at the transcriptional level by qPCR of RNA samples from the same 106 subjects (Supplemental Table 1 ). We also performed multi-plex ELISA analysis, using nasal washes obtained immediately prior to nasal brush sample collection, to confirm the biological impact of these transcriptional changes. As shown in Figure 1E , we validated significant differences in the level of multiple inflammator.....
Document: We validated severity-associated gene expression changes at the transcriptional level by qPCR of RNA samples from the same 106 subjects (Supplemental Table 1 ). We also performed multi-plex ELISA analysis, using nasal washes obtained immediately prior to nasal brush sample collection, to confirm the biological impact of these transcriptional changes. As shown in Figure 1E , we validated significant differences in the level of multiple inflammatory biomarkers associated with severity (eg, CXCL1, CXCL2, IL6), and non-significant differences in others (eg, IL16).
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