Selected article for: "age visit and multivariate analysis"
Author: Chin-Yi Chu; Xing Qiu; Matthew N. McCall; Lu Wang; Anthony Corbett; Jeanne Holden-Wiltse; Christopher Slaunwhite; Qian Wang; Christopher Anderson; Alex Grier; Steven R. Gill; Gloria S. Pryhuber; Ann R. Falsey; David J. Topham; Mary T. Caserta; Edward E. Walsh; Thomas J Mariani
Title: Insufficiency in airway interferon activation defines clinical severity to infant RSV infection
  • Document date: 2019_5_20
    • ID: bx49tbui_71
    Snippet: Given the substantial impact of the presence of bacterial pathogens on airway gene expression in asymptomatic 35 and symptomatic subjects (Table 2) , and the singular association of H. influenzae with severity, we sought to identify severity-associated gene expression independent of the impact of H. influenzae. We performed multivariate analysis, similar to as described above, but including the relative abundance of H. influenzae in the model. We.....
    Document: Given the substantial impact of the presence of bacterial pathogens on airway gene expression in asymptomatic 35 and symptomatic subjects (Table 2) , and the singular association of H. influenzae with severity, we sought to identify severity-associated gene expression independent of the impact of H. influenzae. We performed multivariate analysis, similar to as described above, but including the relative abundance of H. influenzae in the model. We identified 643 genes significantly associated with GRSS independent of the presence of H. influenzae and visit age. Analysis of this gene set revealed many genes, pathways (Supplemental Figures 6-8 ) and cell types that were identified in our analysis not including H. influenzae. However, ontological analysis of this gene set identified a greater association with bacterial infection (Fig. 2B) .

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