Author: Christoph Muus; Malte D Luecken; Gokcen Eraslan; Avinash Waghray; Graham Heimberg; Lisa Sikkema; Yoshihiko Kobayashi; Eeshit Dhaval Vaishnav; Ayshwarya Subramanian; Christopher Smillie; Karthik Jagadeesh; Elizabeth Thu Duong; Evgenij Fiskin; Elena Torlai Triglia; Christophe Becavin; Meshal Ansari; Peiwen Cai; Brian Lin; Justin Buchanan; Sijia Chen; Jian Shu; Adam L Haber; Hattie Chung; Daniel T Montoro; Taylor Adams; Hananeh Aliee; Samuel J Allon; Zaneta Andrusivova; Ilias Angelidis; Orr Ashenberg; Kevin Bassler; Christophe Becavin; Inbal Benhar; Joseph Bergenstrahle; Ludvig Bergenstrahle; Liam Bolt; Emelie Braun; Linh T Bui; Mark Chaffin; Evgeny Chichelnitskiy; Joshua Chiou; Thomas M Conlon; Michael S Cuoco; Marie Deprez; David S Fischer; Astrid Gillich; Joshua Gould; Minzhe Guo; Austin J Gutierrez; Arun C Habermann; Tyler Harvey; Peng He; Xiaomeng Hou; Lijuan Hu; Alok Jaiswal; Peiyong Jiang; Theodoros Kapellos; Christin S Kuo; Ludvig Larsson; Michael A Leney-Greene; Kyungtae Lim; Monika Litvinukova; Ji Lu; Leif S Ludwig; Wendy Luo; Henrike Maatz; Elo Maddissoon; Lira Mamanova; Kasidet Manakongtreecheep; Charles-Hugo Marquette; Ian Mbano; Alexi M McAdams; Ross J Metzger; Ahmad N Nabhan; Sarah K Nyquist; Jose Ordovas-Montanes; Lolita Penland; Olivier B Poirion; Segio Poli; CanCan Qi; Daniel Reichart; Ivan Rosas; Jonas Schupp; Rahul Sinha; Rene V Sit; Kamil Slowikowski; Michal Slyper; Neal Smith; Alex Sountoulidis; Maximilian Strunz; Dawei Sun; Carlos Talavera-Lopez; Peng Tan; Jessica Tantivit; Kyle J Travaglini; Nathan R Tucker; Katherine Vernon; Marc H Wadsworth; Julia Waldman; Xiuting Wang; Wenjun Yan; Ali Onder Yildirim; William Zhao; Carly G K Ziegler; Aviv Regev
Title: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells Document date: 2020_4_20
ID: nkql7h9x_1
Snippet: the receptor for both SARS-CoV 40 and SARS-CoV-2. The receptor-binding domain of the SARS-CoV-2 S-protein has a higher binding affinity for human ACE2 than SARS-CoV 36, 41 , whereas the interaction with CD147 (encoded by the gene BSG), another reported receptor for the SARS-CoV-2 S-protein, is weak (CD147: Kd, 0.185 µM vs hACE2: Kd, ~15 nM) 42 . Following receptor binding, the virus gains access to the host cell cytosol through acid-dependent pr.....
Document: the receptor for both SARS-CoV 40 and SARS-CoV-2. The receptor-binding domain of the SARS-CoV-2 S-protein has a higher binding affinity for human ACE2 than SARS-CoV 36, 41 , whereas the interaction with CD147 (encoded by the gene BSG), another reported receptor for the SARS-CoV-2 S-protein, is weak (CD147: Kd, 0.185 µM vs hACE2: Kd, ~15 nM) 42 . Following receptor binding, the virus gains access to the host cell cytosol through acid-dependent proteolytic cleavage of the S protein. For SARS-CoV, a number of proteases including TMPRSS2 and CTSL cleave at the S1 and S2 boundary and S2 domain (S2') 43 to mediate membrane fusion and virus infectivity. For SARS-CoV-2, both pharmacological inhibition of endogenous TMPRSS2 protein and TMPRSS2 overexpression support a role for TMPRSS2-mediated cellular entry 37, 44 .
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