Author: Gallo, Gaetano; Tiesi, Vincenzo; Fulginiti, Serena; De Paola, Gilda; Vescio, Giuseppina; Sammarco, Giuseppe
Title: Mesenchymal Stromal Cell Therapy in the Management of Perianal Fistulas in Crohn’s Disease: An Up-To-Date Review Cord-id: zr5nrnqt Document date: 2020_10_27
ID: zr5nrnqt
Snippet: Crohn’s Disease (CD) is a chronic inflammatory disorder that potentially involves the entire gastrointestinal tract. Perianal fistulizing CD (pCD) is a serious and frequent complication associated with significant morbidities and a heavy negative impact on quality of life. The aim of CD treatment is to induce and maintain disease remission and to promote mucosal repair. Unfortunately, even the best therapeutic regimens in pCD do not have long-term efficacy and cause a significant number of sid
Document: Crohn’s Disease (CD) is a chronic inflammatory disorder that potentially involves the entire gastrointestinal tract. Perianal fistulizing CD (pCD) is a serious and frequent complication associated with significant morbidities and a heavy negative impact on quality of life. The aim of CD treatment is to induce and maintain disease remission and to promote mucosal repair. Unfortunately, even the best therapeutic regimens in pCD do not have long-term efficacy and cause a significant number of side effects. Therefore, it is mandatory to study new therapeutical options such as the use of mesenchymal stromal cells (MSCs). These cells promote tissue repair via the induction of immunomodulation. The present review aims to analyze the existing updated scientific literature on MSCs adoption in the treatment of pCD to evaluate its efficacy and safety and to compare the use of bone marrow and adipose tissue derived MSCs, type of administration, and dose required for recovery.
Search related documents:
Co phrase search for related documents- abdominal pain and abscess formation: 1, 2, 3
- abdominal pain and activity index: 1, 2, 3, 4
- abdominal pain and adipose tissue: 1, 2, 3
- abdominal pain and local inflammation: 1, 2
- abdominal pain and local injection: 1, 2, 3
- abdominal pain and local treatment: 1
- abdominal pain and long term follow: 1, 2, 3, 4, 5
- abdominal pain and low remain: 1
- abdominal pain and lupus erythematosus: 1, 2, 3, 4
- abdominal surgery and abscess drainage: 1, 2
- abdominal surgery and abscess formation: 1
- abdominal surgery and active group: 1
- abdominal surgery and local injection: 1
- abdominal surgery and local treatment: 1, 2
- abdominal surgery and long term follow: 1, 2, 3, 4, 5, 6
- abdominal surgery and long term follow study: 1
- abscess drainage and local treatment: 1
- abscess drainage and long term follow: 1
- abscess formation and local treatment: 1
Co phrase search for related documents, hyperlinks ordered by date