Selected article for: "disease course and inflammatory reaction"
Author: JIan Chen; Hua Fan; Lin Zhang; Bin Huang; Muxin Zhu; Yong Zhou; WenHu Yu; Liping Zhu; Shaohui Cheng; Xiaogen Tao; Huan Zhang
Title: Retrospective Analysis of Clinical Features in 101 Death Cases with COVID-19
  • Document date: 2020_3_12
    • ID: 9ynljm2r_27
    Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.09.20033068 doi: medRxiv preprint before deaths, significantly higher than results reported by Chen et al [9] ， indicating a severe inflammatory reaction.We found that 23 ( and angiotensin-converting enzyme 2 (ACE2) has been confirmed as a common pathogenic receptor [19] . Thirty one percent of ICU patients were found to have significan.....
    Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.09.20033068 doi: medRxiv preprint before deaths, significantly higher than results reported by Chen et al [9] ， indicating a severe inflammatory reaction.We found that 23 ( and angiotensin-converting enzyme 2 (ACE2) has been confirmed as a common pathogenic receptor [19] . Thirty one percent of ICU patients were found to have significant abnormalities in Troponin I(TNI) [8] . We noted that TNI was significantly elevated in the ICU patients or before deaths compared with primary admission to hospital. Further analysis revealed that patients who were hospitalized with elevated troponin underwent a fast progress from onset to ICU and to death. The results suggest that heart is a potential targeted organ by 2019-nCOV in the disease process. Thus monitoring and prediction of heart injury would be needed at early stage as well as in the course of disease.

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