Author: Julien Riou; Anthony Hauser; Michel J Counotte; Christian L Althaus
Title: Adjusted age-specific case fatality ratio during the COVID-19 epidemic in Hubei, China, January and February 2020 Document date: 2020_3_6
ID: mrsya6wz_30
Snippet: Our results also come with several limitations. First, we assume that the deficit of reported cases among younger age groups is a result of preferential ascertainment, whereby younger individuals have milder symptoms and are less likely to seek care, and does not reflect a lower risk of infection in younger individuals. The reason for the shifted age distribution of reported cases is unclear. During the pandemic of H1N1 influenza, lower circulati.....
Document: Our results also come with several limitations. First, we assume that the deficit of reported cases among younger age groups is a result of preferential ascertainment, whereby younger individuals have milder symptoms and are less likely to seek care, and does not reflect a lower risk of infection in younger individuals. The reason for the shifted age distribution of reported cases is unclear. During the pandemic of H1N1 influenza, lower circulation in older individuals was attributed to residual immunity [24] . Lower susceptibility of younger individuals for immunological reasons seems unlikely. There is no indication of pre-existing immunity to SARS-CoV-2 in humans [4] . Different contact patterns could contribute to different attack rates by age group, but we include age-specific contact patterns in the model.
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