Author: Denisa Bojkova; Jake E. McGreig; Katie-May McLaughlin; Stuart G. Masterson; Marek Widera; Verena Krähling; Sandra Ciesek; Mark N. Wass; Martin Michaelis; Jindrich Cinatl
Title: SARS-CoV-2 and SARS-CoV differ in their cell tropism and drug sensitivity profiles Document date: 2020_4_5
ID: gpr86lxe_5
Snippet: positions are DCPs (243 residues, 1%) (Table 1) . SARS-CoV entry depends on the 165 cleavage of S by transmembrane serine protease 2 (TMPRSS2), the endosomal 166 cysteine protease cathepsin L, and/ or other cellular proteases, with residues R667 167 and R797 being critical cleavage sites [ by the SARS-CoV-2 residue) ( Figure 1A ). There is greater conservation around the 176 R815 cleavage site with only two DCPs in close proximity (L792=S810, T79.....
Document: positions are DCPs (243 residues, 1%) (Table 1) . SARS-CoV entry depends on the 165 cleavage of S by transmembrane serine protease 2 (TMPRSS2), the endosomal 166 cysteine protease cathepsin L, and/ or other cellular proteases, with residues R667 167 and R797 being critical cleavage sites [ by the SARS-CoV-2 residue) ( Figure 1A ). There is greater conservation around the 176 R815 cleavage site with only two DCPs in close proximity (L792=S810, T795=S813) 177
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