Selected article for: "copy number and primer probe"
Author: Renfei Lu; Jian Wang; Min Li; Yaqi Wang; Jia Dong; Weihua Cai
Title: SARS-CoV-2 detection using digital PCR for COVID-19 diagnosis, treatment monitoring and criteria for discharge
  • Document date: 2020_3_30
    • ID: mskkahwi_28
    Snippet: The dPCR results also showed higher sensitivity when the primer and probe are designed against N 248 gene. It may be explained by the higher copy number of RNA for N gene arising from the replication 249 process of the virus 17,18 . Interestingly, RT-PCR assay didn't exhibit significance difference between the 250 two targets. Further study is warranted to elucidate the underlying mechanism. It is well recognized 251 that dPCR assays are less sus.....
    Document: The dPCR results also showed higher sensitivity when the primer and probe are designed against N 248 gene. It may be explained by the higher copy number of RNA for N gene arising from the replication 249 process of the virus 17,18 . Interestingly, RT-PCR assay didn't exhibit significance difference between the 250 two targets. Further study is warranted to elucidate the underlying mechanism. It is well recognized 251 that dPCR assays are less susceptible to the existence of PCR inhibitors, and the results are thus more 252 reliable in general 11, 19 . 253

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