Selected article for: "low expression and lung cells"
Author: Christoph Muus; Malte D Luecken; Gokcen Eraslan; Avinash Waghray; Graham Heimberg; Lisa Sikkema; Yoshihiko Kobayashi; Eeshit Dhaval Vaishnav; Ayshwarya Subramanian; Christopher Smillie; Karthik Jagadeesh; Elizabeth Thu Duong; Evgenij Fiskin; Elena Torlai Triglia; Christophe Becavin; Meshal Ansari; Peiwen Cai; Brian Lin; Justin Buchanan; Sijia Chen; Jian Shu; Adam L Haber; Hattie Chung; Daniel T Montoro; Taylor Adams; Hananeh Aliee; Samuel J Allon; Zaneta Andrusivova; Ilias Angelidis; Orr Ashenberg; Kevin Bassler; Christophe Becavin; Inbal Benhar; Joseph Bergenstrahle; Ludvig Bergenstrahle; Liam Bolt; Emelie Braun; Linh T Bui; Mark Chaffin; Evgeny Chichelnitskiy; Joshua Chiou; Thomas M Conlon; Michael S Cuoco; Marie Deprez; David S Fischer; Astrid Gillich; Joshua Gould; Minzhe Guo; Austin J Gutierrez; Arun C Habermann; Tyler Harvey; Peng He; Xiaomeng Hou; Lijuan Hu; Alok Jaiswal; Peiyong Jiang; Theodoros Kapellos; Christin S Kuo; Ludvig Larsson; Michael A Leney-Greene; Kyungtae Lim; Monika Litvinukova; Ji Lu; Leif S Ludwig; Wendy Luo; Henrike Maatz; Elo Maddissoon; Lira Mamanova; Kasidet Manakongtreecheep; Charles-Hugo Marquette; Ian Mbano; Alexi M McAdams; Ross J Metzger; Ahmad N Nabhan; Sarah K Nyquist; Jose Ordovas-Montanes; Lolita Penland; Olivier B Poirion; Segio Poli; CanCan Qi; Daniel Reichart; Ivan Rosas; Jonas Schupp; Rahul Sinha; Rene V Sit; Kamil Slowikowski; Michal Slyper; Neal Smith; Alex Sountoulidis; Maximilian Strunz; Dawei Sun; Carlos Talavera-Lopez; Peng Tan; Jessica Tantivit; Kyle J Travaglini; Nathan R Tucker; Katherine Vernon; Marc H Wadsworth; Julia Waldman; Xiuting Wang; Wenjun Yan; Ali Onder Yildirim; William Zhao; Carly G K Ziegler; Aviv Regev
Title: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
  • Document date: 2020_4_20
    • ID: nkql7h9x_19
    Snippet: The age associations highlighted particularly low expression in samples from very young children (newborn to 3 years old). As reports suggest that most infants and young children cases do not display severe disease 11, 74 , we inspected the subsets of studies of human development and pediatric samples from our integrated analysis (Supplementary Table 2 ). These included cells from 12 first trimester samples (8 donors) of fetal lung (8.5 weeks pos.....
    Document: The age associations highlighted particularly low expression in samples from very young children (newborn to 3 years old). As reports suggest that most infants and young children cases do not display severe disease 11, 74 , we inspected the subsets of studies of human development and pediatric samples from our integrated analysis (Supplementary Table 2 ). These included cells from 12 first trimester samples (8 donors) of fetal lung (8.5 weeks post conception; wpc), 29 fetal lung samples (26 donors) from the second trimester (13-24 weeks) 68 , 13 lung samples (10 donors) spanning from third trimester premature births (n=4), full term newborns (n=1), ~3-month old (n=4), 3-year-old (n=3), and 10-year-old (n=1) children. Because the number of samples here is small, all observations must be interpreted with caution.

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