Author: Fiil, Berthe Katrine; Gyrd-Hansen, Mads
Title: The Met1-linked ubiquitin machinery in inflammation and infection Cord-id: qz4sfwo8 Document date: 2021_1_20
ID: qz4sfwo8
Snippet: Ubiquitination is an essential post-translational modification that regulates most cellular processes. The assembly of ubiquitin into polymeric chains by E3 ubiquitin ligases underlies the pleiotropic functions ubiquitin chains regulate. Ubiquitin chains assembled via the N-terminal methionine, termed Met1-linked ubiquitin chains or linear ubiquitin chains, have emerged as essential signalling scaffolds that regulate pro-inflammatory responses, anti-viral interferon responses, cell death and xen
Document: Ubiquitination is an essential post-translational modification that regulates most cellular processes. The assembly of ubiquitin into polymeric chains by E3 ubiquitin ligases underlies the pleiotropic functions ubiquitin chains regulate. Ubiquitin chains assembled via the N-terminal methionine, termed Met1-linked ubiquitin chains or linear ubiquitin chains, have emerged as essential signalling scaffolds that regulate pro-inflammatory responses, anti-viral interferon responses, cell death and xenophagy of bacterial pathogens downstream of innate immune receptors. Met1-linked ubiquitin chains are exclusively assembled by the linear ubiquitin chain assembly complex, LUBAC, and are disassembled by the deubiquitinases OTULIN and CYLD. Genetic defects that perturb the regulation of Met1-linked ubiquitin chains causes severe immune-related disorders, illustrating their potent signalling capacity. Here, we review the current knowledge about the cellular machinery that conjugates, recognises, and disassembles Met1-linked ubiquitin chains, and discuss the function of this unique posttranslational modification in regulating inflammation, cell death and immunity to pathogens.
Search related documents:
Co phrase search for related documents- action mechanism and acute infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- action mechanism and adaptive immune response: 1, 2, 3
- action mechanism and adaptive immune response regulation: 1
- action mechanism and adaptor protein: 1
- action mechanism understand and acute infection: 1
- activate receptor and acute infection: 1
- activate receptor and adaptive immune response: 1
- activation recruitment and acute infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- activation recruitment and adaptive immune response: 1, 2, 3, 4
- activation recruitment and adaptor protein: 1, 2, 3, 4, 5, 6, 7
- activity interfere and adaptive immune response: 1
- activity regulate and adaptor protein: 1
- acute infection and adaptive immune response: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute infection and adaptor protein: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date