Mat_Peptide: Comprehensive annotation of mature peptides from polyproteins in five virus families.

Larsen, Christopher N; Sun, Guangyu; Li, Xiaomei; Zaremba, Sam; Zhao, Hongtao; He, Sherry; Zhou, Liwei; Kumar, Sanjeev; Desborough, Vince; Klem, Edward B

SUMMARY Post-translational proteolytic processing of polyproteins into mature peptides has been performed in silico, with a new computational method, for over 200 species in five pathogenic virus families (Caliciviridae, Coronaviridae, Flaviviridae, Picornaviridae, and Togaviridae). Using pairwise alignment with reference sequences, mature peptides have been annotated and their sequences made available for search, analysis, and download. MOTIVATION Sequence repositories have few annotated virus mature peptide sequences. RESULTS The method produced 156,216 sequences to date, a large portion of the protein sequences available in viprbrc.org. It represents a new and comprehensive mature peptide collection. AVAILABILITY AND IMPLEMENTATION The data are available at the Virus Pathogen Resource https://www.viprbrc.org, and the software at https://github.com/VirusBRC/vipr_mat_peptide. SUPPLEMENTARY INFORMATION Supplementary data and methods are at the GitHub software repository.