Selected article for: "genome replication and RNA dependent RNA polymerase"
Author: Yu-Nong Gong; Kuo-Chien Tsao; Mei-Jen Hsiao; Chung-Guei Huang; Peng-Nien Huang; Po-Wei Huang; Kuo-Ming Lee; Yi-Chun Liu; Shu-Li Yang; Rei-Lin Kuo; Ming-Tsan Liu; Ji-Rong Yang; Cheng-Hsun Chiu; Cheng-Ta Yang; Shin-Ru Shih; Guang-Wu Chen
Title: Sequence variation among SARS-CoV-2 isolates in Taiwan
  • Document date: 2020_3_31
    • ID: 6phwc7s7_4
    Snippet: RNA viruses show variations in their genomes due to nucleotide substitutions generated 1 9 0 by the low fidelity of RNA-dependent RNA polymerase during replication. The genome 1 9 1 variation of these viruses is thought to facilitate successful adaption to the environment of 1 9 2 various hosts. However, previous studies showed that the mutation rates of RNA viruses vary in CoV-2 isolated from 5 patients from February 26 to March 9, 2020 in CGMH .....
    Document: RNA viruses show variations in their genomes due to nucleotide substitutions generated 1 9 0 by the low fidelity of RNA-dependent RNA polymerase during replication. The genome 1 9 1 variation of these viruses is thought to facilitate successful adaption to the environment of 1 9 2 various hosts. However, previous studies showed that the mutation rates of RNA viruses vary in CoV-2 isolated from 5 patients from February 26 to March 9, 2020 in CGMH Taiwan revealed 1 9 5 only 4 mutations in their 29,903-nt genomic RNA. This suggests that the nucleotide substitution 1 9 6 rate is controlled during viral RNA replication. The nsp14 exoribonuclease encoded by several 1 9 7 coronaviruses plays a role in proofreading during genome replication (13, 14) ; further studies are 1 9 8 required to investigate the function of SARS-CoV-2 nsp14 in replication fidelity. Timely sharing full genomes of SASR-CoV-2 from different locations is important for author/funder. All rights reserved. No reuse allowed without permission.

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