Author: K, Nithin K.; Patil, Prakash; Bhandary, Satheesh Kumar; Haridas, Vikram; N, Suchetha Kumari; E, Sarathkumar; Shetty, Praveenkumar
Title: Is butyrate a natural alternative to dexamethasone in the management of CoVID-19? Cord-id: z23nmpdy Document date: 2021_4_6
ID: z23nmpdy
Snippet: Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, is being used to manage the cytokine storm and hyperinflammation in CoVID-19 patients. However, the extensive use of corticosteroids le
Document: Coronavirus disease 2019 (CoVID-19) caused by Severe Acute Respiratory Syndrome Coronavirus 2 has affected more than 100 million lives. Severe CoVID-19 infection may lead to acute respiratory distress syndrome and death of the patient, and is associated with hyperinflammation and cytokine storm. The broad spectrum immunosuppressant corticosteroid, dexamethasone, is being used to manage the cytokine storm and hyperinflammation in CoVID-19 patients. However, the extensive use of corticosteroids leads to serious adverse events and disruption of the gut-lung axis. Various micronutrients and probiotic supplementations are known to aid in the reduction of hyperinflammation and restoration of gut microbiota. The attenuation of the deleterious immune response and hyperinflammation could be mediated by short chain fatty acids produced by the gut microbiota. Butyric acid, the most extensively studied short chain fatty acid, is known for its anti-inflammatory properties. Additionally, butyric acid has been shown to ameliorate hyperinflammation and reduce oxidative stress in various pathologies, including respiratory viral infections. In this review, the potential anti-inflammatory effects of butyric acid that aid in cytokine storm depletion, and its usefulness in effective management of critical illness related to CoVID-19 have been discussed.
Search related documents:
Co phrase search for related documents- abdominal pain and acute cardiac injury: 1, 2
- abdominal pain and acute kidney injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- abdominal pain and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- aberrant inflammation and acute ards respiratory distress syndrome: 1, 2, 3, 4, 5
- aberrant inflammation and acute kidney injury: 1
- aberrant inflammation and acute lung injury: 1
- acid docosahexaenoic eicosapentaenoic acid and acute ards respiratory distress syndrome: 1
- activated mapk protein kinase and acute ards respiratory distress syndrome: 1, 2, 3, 4
- activated mapk protein kinase and acute kidney injury: 1, 2
- activated mapk protein kinase and acute lung injury: 1, 2, 3, 4, 5, 6, 7, 8
- active site and acute ards respiratory distress syndrome: 1, 2
- active site and acute lung injury: 1, 2
- active site and liver injury: 1
- acute ards respiratory distress syndrome and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- acute cardiac injury and liver injury: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date