Author: Corey T Watson; Karyn Meltz Steinberg; Tina A Graves-Lindsay; Rene L Warren; Maika Malig; Jacqueline E Schein; Richard K Wilson; Rob Holt; Evan Eichler; Felix Breden
Title: Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity Document date: 2014_7_3
ID: 62gfisc6_22
Snippet: Supplementary Figure 2A ). Interestingly, SNP density within 1 Mbp of the q arm telomere of chr14 harbouring IGHV (0.002) was higher than all other telomeric regions, >2-fold higher than the telomeric average (Supplementary Figure 2B) . In contrast, when CHM1 SNP densities within 3 Mbp of all telomeres were compared, the region on the q arm of ch14 (including both IGHV and non-IGHV sequence) no longer stands out, suggesting that IGHV may have som.....
Document: Supplementary Figure 2A ). Interestingly, SNP density within 1 Mbp of the q arm telomere of chr14 harbouring IGHV (0.002) was higher than all other telomeric regions, >2-fold higher than the telomeric average (Supplementary Figure 2B) . In contrast, when CHM1 SNP densities within 3 Mbp of all telomeres were compared, the region on the q arm of ch14 (including both IGHV and non-IGHV sequence) no longer stands out, suggesting that IGHV may have some unique properties contributing to higher than average genetic diversity. To place this in the context of the analysis conducted within the IG regions above, we also found that the q arm of ch14 has the second highest overlap with SDs (34%; Supplementary Figure 3 ).
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