Author: Ke Wang; Wei Chen; Yu-Sen Zhou; Jian-Qi Lian; Zheng Zhang; Peng Du; Li Gong; Yang Zhang; Hong-Yong Cui; Jie-Jie Geng; Bin Wang; Xiu-Xuan Sun; Chun-Fu Wang; Xu Yang; Peng Lin; Yong-Qiang Deng; Ding Wei; Xiang-Min Yang; Yu-Meng Zhu; Kui Zhang; Zhao-Hui Zheng; Jin-Lin Miao; Ting Guo; Ying Shi; Jun Zhang; Ling Fu; Qing-Yi Wang; Huijie Bian; Ping Zhu; Zhi-Nan Chen
Title: SARS-CoV-2 invades host cells via a novel route: CD147-spike protein Document date: 2020_3_14
ID: 5hpbjkft_13
Snippet: To further determine the localization of CD147 and SP in the process of viral infection, the Vero E6 cells infected with SARS-CoV-2 were observed by immune-electron microscope. After traced by 10 nm (CD147) and 20 nm (SP) gold colloid-labeled antibodies, we found that the two proteins mainly presented in viral inclusion bodies of Vero E6 cells ( Figure 3A -C). These results reinforce the finding that the CD147-SP interaction enhances viral invasi.....
Document: To further determine the localization of CD147 and SP in the process of viral infection, the Vero E6 cells infected with SARS-CoV-2 were observed by immune-electron microscope. After traced by 10 nm (CD147) and 20 nm (SP) gold colloid-labeled antibodies, we found that the two proteins mainly presented in viral inclusion bodies of Vero E6 cells ( Figure 3A -C). These results reinforce the finding that the CD147-SP interaction enhances viral invasion for host cells.
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