Selected article for: "low expression tissue and lung include"
Author: Christoph Muus; Malte D Luecken; Gokcen Eraslan; Avinash Waghray; Graham Heimberg; Lisa Sikkema; Yoshihiko Kobayashi; Eeshit Dhaval Vaishnav; Ayshwarya Subramanian; Christopher Smillie; Karthik Jagadeesh; Elizabeth Thu Duong; Evgenij Fiskin; Elena Torlai Triglia; Christophe Becavin; Meshal Ansari; Peiwen Cai; Brian Lin; Justin Buchanan; Sijia Chen; Jian Shu; Adam L Haber; Hattie Chung; Daniel T Montoro; Taylor Adams; Hananeh Aliee; Samuel J Allon; Zaneta Andrusivova; Ilias Angelidis; Orr Ashenberg; Kevin Bassler; Christophe Becavin; Inbal Benhar; Joseph Bergenstrahle; Ludvig Bergenstrahle; Liam Bolt; Emelie Braun; Linh T Bui; Mark Chaffin; Evgeny Chichelnitskiy; Joshua Chiou; Thomas M Conlon; Michael S Cuoco; Marie Deprez; David S Fischer; Astrid Gillich; Joshua Gould; Minzhe Guo; Austin J Gutierrez; Arun C Habermann; Tyler Harvey; Peng He; Xiaomeng Hou; Lijuan Hu; Alok Jaiswal; Peiyong Jiang; Theodoros Kapellos; Christin S Kuo; Ludvig Larsson; Michael A Leney-Greene; Kyungtae Lim; Monika Litvinukova; Ji Lu; Leif S Ludwig; Wendy Luo; Henrike Maatz; Elo Maddissoon; Lira Mamanova; Kasidet Manakongtreecheep; Charles-Hugo Marquette; Ian Mbano; Alexi M McAdams; Ross J Metzger; Ahmad N Nabhan; Sarah K Nyquist; Jose Ordovas-Montanes; Lolita Penland; Olivier B Poirion; Segio Poli; CanCan Qi; Daniel Reichart; Ivan Rosas; Jonas Schupp; Rahul Sinha; Rene V Sit; Kamil Slowikowski; Michal Slyper; Neal Smith; Alex Sountoulidis; Maximilian Strunz; Dawei Sun; Carlos Talavera-Lopez; Peng Tan; Jessica Tantivit; Kyle J Travaglini; Nathan R Tucker; Katherine Vernon; Marc H Wadsworth; Julia Waldman; Xiuting Wang; Wenjun Yan; Ali Onder Yildirim; William Zhao; Carly G K Ziegler; Aviv Regev
Title: Integrated analyses of single-cell atlases reveal age, gender, and smoking status associations with cell type-specific expression of mediators of SARS-CoV-2 viral entry and highlights inflammatory programs in putative target cells
  • Document date: 2020_4_20
    • ID: nkql7h9x_31
    Snippet: Some program genes may be particularly related to COVID19 pathological features and may indicate putative therapeutic targets. For example, MUC1 is especially highly induced in dualpositive cells (in tissue and specific cell programs), which may be associated with respiratory secretions 91 . Importantly, the lung tissue and gut enterocyte programs include the gene encoding the IL6 co-receptor (IL6ST), and the AT2 cell program includes IL6. IL6 si.....
    Document: Some program genes may be particularly related to COVID19 pathological features and may indicate putative therapeutic targets. For example, MUC1 is especially highly induced in dualpositive cells (in tissue and specific cell programs), which may be associated with respiratory secretions 91 . Importantly, the lung tissue and gut enterocyte programs include the gene encoding the IL6 co-receptor (IL6ST), and the AT2 cell program includes IL6. IL6 signaling has been implicated in uncontrolled immune responses in the lungs of COVID19 patients, elevated serum IL6 levels are associated with the need for mechanical ventilation 92 , and anti-IL6R antibodies (tocilizumab) are being tested for clinical efficacy in COVID-19 patients. Indeed, IL6ST and IL6 are higher in dual positive vs. dual negative AT2 cells (Extended Data Fig. 11d) , although IL6 expression is relatively low in these cells from healthy tissue. Additional cell types, such as heart pericytes, are enriched for cells with co-expression of ACE2 with IL6R or IL6ST (Extended Data Fig. 12 ).

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