Author: Kumari G. Lokugamage; Adam Hage; Craig Schindewolf; Ricardo Rajsbaum; Vineet D. Menachery
Title: SARS-CoV-2 is sensitive to type I interferon pretreatment Document date: 2020_3_9
ID: 2w0zr9c0_13
Snippet: CoV. Using Vero E6 cells, we demonstrate that SARS-CoV-2 maintains similar viral replication 66 kinetics as SARS-CoV following a low dose infection. In contrast, we find that SARS-CoV-2 is 67 much more sensitive to IFN-I pretreatment as compared to SARS-CoV. Examining further, we 68 determined that SARS-CoV-2 induces STAT1 phosphorylation and ISG expression, which is 69 absent in SARS-CoV. Similarly, infection of IFN competent Calu3 2B4 cells res.....
Document: CoV. Using Vero E6 cells, we demonstrate that SARS-CoV-2 maintains similar viral replication 66 kinetics as SARS-CoV following a low dose infection. In contrast, we find that SARS-CoV-2 is 67 much more sensitive to IFN-I pretreatment as compared to SARS-CoV. Examining further, we 68 determined that SARS-CoV-2 induces STAT1 phosphorylation and ISG expression, which is 69 absent in SARS-CoV. Similarly, infection of IFN competent Calu3 2B4 cells resulted in reduced 70 SARS-Cov-2 replication and STAT1 phosphorylation at late times. These results suggest 71 distinct changes between the CoVs in terms of IFN antagonism and we subsequently examined 72 sequence homology between the SARS-CoV and SARS-CoV-2 viral proteins that may be 73 responsible for these differences. Together, the results suggest SARS-CoV-2 lacks the same 74 capacity to control the IFN-I response as SARS-CoV. 75
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