Author: Kumari G. Lokugamage; Adam Hage; Craig Schindewolf; Ricardo Rajsbaum; Vineet D. Menachery
Title: SARS-CoV-2 is sensitive to type I interferon pretreatment Document date: 2020_3_9
ID: 2w0zr9c0_33
Snippet: Importantly, SARS-CoV-2 has a two amino acid truncation in its ORF6; previous work has found 173 that alanine substitution in this C-terminal of SARS-CoV ORF6 resulted in ablated antagonism 174 (32). Together, the sequence homology analysis suggests that differences in NSP3, ORF3b, 175 and/or ORF6 may be key drivers of SARS-CoV-2 type I IFN susceptibility. 176 . CC-BY-NC 4.0 International license author/funder. It is made available under a The co.....
Document: Importantly, SARS-CoV-2 has a two amino acid truncation in its ORF6; previous work has found 173 that alanine substitution in this C-terminal of SARS-CoV ORF6 resulted in ablated antagonism 174 (32). Together, the sequence homology analysis suggests that differences in NSP3, ORF3b, 175 and/or ORF6 may be key drivers of SARS-CoV-2 type I IFN susceptibility. 176 . CC-BY-NC 4.0 International license author/funder. It is made available under a The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.07.982264 doi: bioRxiv preprint
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