Author: Alkhaibari, Ibrahim; Raj Kc, Hansa; Alnufaie, Rawan; Gilmore, David F; Alam, Mohammad Abrar
Title: Synthesis of Chimeric Thiazolo-Nootkatone Derivatives as Potent Antimicrobial Agents. Cord-id: wg9zg633 Document date: 2021_5_6
ID: wg9zg633
Snippet: Nootkatone, an approved insecticide, is a well-known natural product from grapefruit. A series of fused-thiazole derivatives of nootkatone have been synthesized and these new compounds were tested against several strains of bacteria. Some of these compounds (15 and 16) are found to be potent antimicrobial agents against Staphylococcus aureus and Enterococcus faecium with minimum inhibitory concentration (MIC) values as low as 1.56 µg/ml. The lead compound (16) is bactericidal and very potent ag
Document: Nootkatone, an approved insecticide, is a well-known natural product from grapefruit. A series of fused-thiazole derivatives of nootkatone have been synthesized and these new compounds were tested against several strains of bacteria. Some of these compounds (15 and 16) are found to be potent antimicrobial agents against Staphylococcus aureus and Enterococcus faecium with minimum inhibitory concentration (MIC) values as low as 1.56 µg/ml. The lead compound (16) is bactericidal and very potent against S. aureus persisters. These compounds are non-toxic to human cancer cell lines at higher concentrations.
Search related documents:
Co phrase search for related documents- Try single phrases listed below for: 1
Co phrase search for related documents, hyperlinks ordered by date