Author: NISREEN M.A. OKBA; Marcel A Muller; Wentao Li; Chunyan Wang; Corine H. GeurtsvanKessel; Victor M. Corman; Mart M. Lamers; Reina S. Sikkema; Erwin de Bruin; Felicity D. Chandler; Yazdan Yazdanpanah; Quentin Le Hingrat; Diane Descamps; Nadhira Houhou-Fidouh; Chantal B. E. M. Reusken; Berend-Jan Bosch; Christian Drosten; Marion P.G. Koopmans; Bart L. Haagmans
Title: SARS-CoV-2 specific antibody responses in COVID-19 patients Document date: 2020_3_20
ID: 9595vm0k_34
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.18.20038059 doi: medRxiv preprint NL63, 7x HCoV-OC43) as well as MERS-CoV (n=3) and SARS-CoV (n=3) infected persons collected 4-56 days post disease onset (Figure 4) . All 9 COVID-19 patients were previously confirmed to seroconvert at days 6-15 post onset of disease using recombinant immunofluorescence test and PRNT. 8/9 seroconverted pa.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.18.20038059 doi: medRxiv preprint NL63, 7x HCoV-OC43) as well as MERS-CoV (n=3) and SARS-CoV (n=3) infected persons collected 4-56 days post disease onset (Figure 4) . All 9 COVID-19 patients were previously confirmed to seroconvert at days 6-15 post onset of disease using recombinant immunofluorescence test and PRNT. 8/9 seroconverted patients showed reactivity above the implemented cut-off values in the IgG and IgA ELISA. One patient (Figure 4 , black line) maintained slightly below the cut-off which might be explained by an overall reduced antibody response of this patient (PRNT90=10). Overall, the IgA-based ELISA kit was more sensitive but less specific than the IgG based ELISA kit.
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