Selected article for: "antibiotic therapy and respiratory panel"
Author: Maataoui, Naouale; Chemali, Lotfi; Patrier, Juliette; Tran Dinh, Alexy; Le Fèvre, Lucie; Lortat-Jacob, Brice; Marzouk, Mehdi; d’Humières, Camille; Rondinaud, Emilie; Ruppé, Etienne; Montravers, Philippe; Timsit, Jean-François; Armand-Lefèvre, Laurence
Title: Impact of rapid multiplex PCR on management of antibiotic therapy in COVID-19-positive patients hospitalized in intensive care unit
  • Cord-id: ygxoqsfb
  • Document date: 2021_3_17
    • ID: ygxoqsfb
    Snippet: Because the diagnosis of co/superinfection in COVID-19 patients is challenging, empirical antibiotic therapy is frequently initiated until microbiological analysis results. We evaluated the performance and the impact of the BioFire® FilmArray® Pneumonia plus Panel on 112 respiratory samples from 67 COVID-19 ICU patients suspected of co/superinfections. Globally, the sensitivity and specificity of the test were 89.3% and 99.1%, respectively. Positive tests led to antibiotic initiation or adapta
    Document: Because the diagnosis of co/superinfection in COVID-19 patients is challenging, empirical antibiotic therapy is frequently initiated until microbiological analysis results. We evaluated the performance and the impact of the BioFire® FilmArray® Pneumonia plus Panel on 112 respiratory samples from 67 COVID-19 ICU patients suspected of co/superinfections. Globally, the sensitivity and specificity of the test were 89.3% and 99.1%, respectively. Positive tests led to antibiotic initiation or adaptation in 15% of episodes and de-escalation in 4%. When negative, 28% of episodes remained antibiotic-free (14% no initiation, 14% withdrawal). Rapid multiplex PCRs can help to improve antibiotic stewardship by administering appropriate antibiotics earlier and avoiding unnecessary prescriptions. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s10096-021-04213-6.

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