Selected article for: "amino acid sequence and different structure"
Author: Jacob Kames; David Dillon Holcomb; Ofer Kimchi; Michael DiCuccio; Nobuko Hamasaki-Katagiri; Tony Wang; Anton A Komar; Aikaterini Alexaki; Chava Kimchi-Sarfaty
Title: Sequence analysis of SARS-CoV-2 genome reveals features important for vaccine design
  • Document date: 2020_3_31
    • ID: 2fn25l6m_13
    Snippet: The genome sequence determines not only the amino acid sequence, but also the structure of the mRNA. The mRNA structure following the frameshift site is expected to be especially biologically relevant, as pseudoknots following programmed ribosomal frameshifts have been found to regulate the efficiency of the frameshift [26, 27] . We therefore sought to study the similarity of the SARS-CoV-2 mRNA structure compared with the structures of different.....
    Document: The genome sequence determines not only the amino acid sequence, but also the structure of the mRNA. The mRNA structure following the frameshift site is expected to be especially biologically relevant, as pseudoknots following programmed ribosomal frameshifts have been found to regulate the efficiency of the frameshift [26, 27] . We therefore sought to study the similarity of the SARS-CoV-2 mRNA structure compared with the structures of different coronavirus mRNAs in the region following the ORF1ab frameshift.

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