Author: Turnbull, Isaiah R; Mazer, Monty B; Hoofnagle, Mark H; Kirby, John P; Leonard, Jennifer M; Mejia-Chew, Carlos; Spec, Andrej; Blood, Jane; Miles, Sydney M; Ransom, Eric M; Potter, Robert F; Gaut, Joseph P; Remy, Kenneth E; Hotchkiss, Richard S
Title: IL-7 Immunotherapy in a Nonimmunocompromised Patient With Intractable Fungal Wound Sepsis Cord-id: r9j939gp Document date: 2021_5_23
ID: r9j939gp
Snippet: A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.
Document: A nonimmunocompromised patient developed life-threatening soft tissue infection with Trichosporon asahii, Fusarium, and Saksenaea that progressed despite maximum antifungal therapies and aggressive debridement. Interleukin-7 immunotherapy resulted in clinical improvement, fungal clearance, reversal of lymphopenia, and improved T-cell function. Immunoadjuvant therapies to boost host immunity may be efficacious in life-threatening fungal infections.
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