Author: Cooper, Keiland W.; Brann, David H.; Farruggia, Michael C.; Bhutani, Surabhi; Pellegrino, Robert; Tsukahara, Tatsuya; Weinreb, Caleb; Joseph, Paule V.; Larson, Eric D.; Parma, Valentina; Albers, Mark W.; Barlow, Linda A.; Datta, Sandeep Robert; Di Pizio, Antonella
Title: COVID-19 and the chemical senses: supporting players take center stage Cord-id: v9ddes3c Document date: 2020_7_1
ID: v9ddes3c
Snippet: Abstract The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given
Document: Abstract The main neurological manifestation of COVID-19 is loss of smell or taste. The high incidence of smell loss without significant rhinorrhea or nasal congestion suggests that SARS-CoV-2 targets the chemical senses through mechanisms distinct from those used by endemic coronaviruses or other common cold-causing agents. Here we review recently developed hypotheses about how SARS-CoV-2 might alter the cells and circuits involved in chemosensory processing and thereby change perception. Given our limited understanding of SARS-CoV-2 pathogenesis, we propose future experiments to elucidate disease mechanisms and highlight the relevance of this ongoing work to understanding how the virus might alter brain function more broadly.
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