Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection During Pregnancy In China: A Retrospective Cohort Study

Mingzhu Yin; Lijuan Zhang; Guangtong Deng; Chaofei Han; Minxue Shen; Hongyin Sun; Furong Zeng; Wei Zhang; Lan Chen; Qingqing Luo; Dujuan Yao; Min Wu; Shihuan Yu; Hui Chen; David Baud; Xiang Chen

Laboratory data demonstrated an increase of white blood cell (WBC) and neutrophil counts in pregnant than non-pregnant patients on admission (WBC count [10 9 /L], 6·95 ± 2·98 vs. 5·11 ± 2·13, p=0·005; neutrophil count [10 9 /L], 5·82 ± 2·59 vs. 3·21 ± 1·89, p< 0·001) ( vs. 21 [65·6%], p=0·002). Level of aspartate aminotransferase were increased in nine (13%) patients, including seven (22·6%) pregnant and two (5·7%) non-pregnant patients ( Table 2 ). Though the concentrations of alanine transaminase and serum creatinine were statistically significant, there was no difference in the proportion of abnormal levels of alanine transaminase and serum creatinine between these two groups. All the enrolled patients underwent the chest CT scan (Fig. S1 ). Sixty-four (97%) patients showed patchy shadows or ground glass, consisting of 30 (96·8%) pregnant and 34 (97·1%) non-pregnant patients. In addition, pregnant and non-pregnant women were administered antiviral therapy (32·2% vs. 57·1%), glucocorticoid therapy (35·4% vs. 14·3%) and oxygen therapy (64·5% vs. 42·8%).