Selected article for: "cycle threshold and respiratory sample"
Author: Gazeau, Pierre; Vallet, Sophie; Ansart, Séverine; Beauruelle, Clémence; Tran-Minoui, Adissa; Payan, Christopher; Pilorgé, Léa
Title: Rapid multiplex PCR assays in patients with respiratory viral infections: is semi-quantitative data useful? A pilot study
  • Cord-id: vhmjg300
  • Document date: 2021_6_9
    • ID: vhmjg300
    Snippet: Viral respiratory rapid multiplex PCR assays FilmArray® (FA) and ePlex® (eP) provide qualitative results which may not reflect clinical relevance. In a pilot study, we report retrospectively whether the semi-quantitative PCR assay R-GENE® would have facilitated clinical interpretation. Forty-four patients were hospitalized for various respiratory manifestations; all of them have benefited from a respiratory sample during acute symptoms. Among the 44 patients, FA detected 23 positive samples i
    Document: Viral respiratory rapid multiplex PCR assays FilmArray® (FA) and ePlex® (eP) provide qualitative results which may not reflect clinical relevance. In a pilot study, we report retrospectively whether the semi-quantitative PCR assay R-GENE® would have facilitated clinical interpretation. Forty-four patients were hospitalized for various respiratory manifestations; all of them have benefited from a respiratory sample during acute symptoms. Among the 44 patients, FA detected 23 positive samples including 31 viruses, 26 of them gave high or moderate R-GENE® scores (cycle threshold < 35), and all but one were consistent with clinical history. Semi-quantitative scores would have allowed for critical interpretation of the results; those are a key additional element for an optimal exploitation of the rapid multiplex PCR assays power.

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