Author: Rijkers, Ger; Murk, Jean-Luc; Wintermans, Bas; Looy, Bieke van; Berge, Marcel van den; Veenemans, Jacobien; Stohr, Joep; Reusken, Chantal; Pol, Pieter van der; Reimerink, Johan
Title: Differences in antibody kinetics and functionality between severe and mild SARS-CoV-2 infections Cord-id: yuwrr4vg Document date: 2020_6_12
ID: yuwrr4vg
Snippet: We determined and compared the humoral immune response in severe, hospitalized and mild, non-hospitalized COVID-19 patients. Severe patients (n=38) develop a robust antibody response to SARS-CoV-2, including IgG and IgA antibodies. The geometric mean 50% virus neutralization titer is 1:240. SARS-CoV-2 infected hospital personnel (n=24), who developed mild symptoms necessitating leave of absence, self-isolation, but not hospitalization, 75 % develop antibodies, but with low/absent virus neutraliz
Document: We determined and compared the humoral immune response in severe, hospitalized and mild, non-hospitalized COVID-19 patients. Severe patients (n=38) develop a robust antibody response to SARS-CoV-2, including IgG and IgA antibodies. The geometric mean 50% virus neutralization titer is 1:240. SARS-CoV-2 infected hospital personnel (n=24), who developed mild symptoms necessitating leave of absence, self-isolation, but not hospitalization, 75 % develop antibodies, but with low/absent virus neutralization (60% < 1:20). While severe COVID-19 patients develop a strong antibody response, mild SARS-CoV-2 infections induce a modest antibody response. Long term monitoring will show whether these responses predict protection against future infections.
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