Author: Wu, Chang-Jer; Jan, Jia-Tsrong; Chen, Chi-Min; Hsieh, Hsing-Pang; Hwang, Der-Ren; Liu, Hwan-Wun; Liu, Chiu-Yi; Huang, Hui-Wen; Chen, Su-Chin; Hong, Cheng-Fong; Lin, Ren-Kuo; Chao, Yu-Sheng; Hsu, John T A
Title: Inhibition of severe acute respiratory syndrome coronavirus replication by niclosamide. Cord-id: v90cvc12 Document date: 2004_1_1
ID: v90cvc12
Snippet: Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 microM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.
Document: Antiviral agents are urgently needed to fight severe acute respiratory syndrome (SARS). We showed that niclosamide, an existing antihelminthic drug, was able to inhibit replication of a newly discovered coronavirus, SARS-CoV; viral antigen synthesis was totally abolished at a niclosamide concentration of 1.56 microM, as revealed by immunoblot analysis. Thus, niclosamide represents a promising drug candidate for the effective treatment of SARS-CoV infection.
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