Author: Chang, Chung-ke; Sue, Shih-Che; Yu, Tsan-hung; Hsieh, Chiu-Min; Tsai, Cheng-Kun; Chiang, Yen-Chieh; Lee, Shin-jye; Hsiao, Hsin-hao; Wu, Wen-Jin; Chang, Chi-Fon; Huang, Tai-huang
Title: The dimer interface of the SARS coronavirus nucleocapsid protein adapts a porcine respiratory and reproductive syndrome virus-like structure Cord-id: zv8lm4jf Document date: 2005_10_24
ID: zv8lm4jf
Snippet: We have employed NMR to investigate the structure of SARS coronavirus nucleocapsid protein dimer. We found that the secondary structure of the dimerization domain consists of five α helices and a β-hairpin. The dimer interface consists of a continuous four-stranded β-sheet superposed by two long α helices, reminiscent of that found in the nucleocapsid protein of porcine respiratory and reproductive syndrome virus. Extensive hydrogen bond formation between the two hairpins and hydrophobic int
Document: We have employed NMR to investigate the structure of SARS coronavirus nucleocapsid protein dimer. We found that the secondary structure of the dimerization domain consists of five α helices and a β-hairpin. The dimer interface consists of a continuous four-stranded β-sheet superposed by two long α helices, reminiscent of that found in the nucleocapsid protein of porcine respiratory and reproductive syndrome virus. Extensive hydrogen bond formation between the two hairpins and hydrophobic interactions between the β-sheet and the α helices render the interface highly stable. Sequence alignment suggests that other coronavirus may share the same structural topology.
Search related documents:
Co phrase search for related documents- acute respiratory syndrome and long flexible: 1
- acute respiratory syndrome and long helix: 1, 2, 3, 4
- acute respiratory syndrome and magnetic resonance: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- additional target and magnetic resonance: 1
- long helix and magnetic resonance: 1
Co phrase search for related documents, hyperlinks ordered by date