Author: Bruna GG Pinto; Antonio ER Oliveira; Youvika Singh; Leandro Jimenez; Andre NA Goncalves; Rodrigo LT Ogava; Rachel Creighton; Jean PS Peron; Helder I Nakaya
Title: ACE2 Expression is Increased in the Lungs of Patients with Comorbidities Associated with Severe COVID-19 Document date: 2020_3_27
ID: 2un9aggj_30
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.03.21.20040261 doi: medRxiv preprint human lung, peaks for H3K4me1 and H3K4me3, as well as H3K27ac, were identified in ACE2 locus (Figure 4c ), suggesting that ACE2 may be epigenetically regulated in the lung. Figure 4 . Insights of ACE2 regulation in the lung. a. Genes whose expression is correlated with ACE2 in the lung. Selected genes tha.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.03.21.20040261 doi: medRxiv preprint human lung, peaks for H3K4me1 and H3K4me3, as well as H3K27ac, were identified in ACE2 locus (Figure 4c ), suggesting that ACE2 may be epigenetically regulated in the lung. Figure 4 . Insights of ACE2 regulation in the lung. a. Genes whose expression is correlated with ACE2 in the lung. Selected genes that were negatively (blue) or positively (red) correlated with ACE2 are highlighted. b. Pathway enrichment analysis using the ACE2-positively correlated genes. Pathways from the "ChIP-X Enrichment Analysis" and "Epigenomics Roadmap" databases with Adjusted P-value < 10 -10 were selected. The size of the red circles is proportional to the -log10 Adjusted P-value of the enrichment. c.
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