Author: Alessandra Renieri; Elisa Benetti; Rossella Tita; Ottavia Spiga; Andrea Ciolfi; Giovanni Birolo; Alessandro Bruselles; Gabriella Doddato; Annarita Giliberti; Cterina Marconi; Francesco Musacchia; Tommaso Pippucci; Annalaura Torella; Alfonso Trezza; Floriana Valentino; Mrgherita Baldassarri; Alfredo Brusco; Rosanna Asselta; Bruttini Mirella; Simone Furini; Marco Seri; Vincenzo Nigro; Giuseppe Matullo; Marco Tartaglia; Francesca Mari; Annamaria Pinto
Title: ACE2 variants underlie interindividual variability and susceptibility to COVID-19 in Italian population Document date: 2020_4_6
ID: klj710h2_21
Snippet: We integrated genomic data from 5 Italian centers (Siena, Naple, Turin, Bologna Along with these more common variants we also identified very rare variants, some of which only described in the non-Finnish European population. Some of them are able to affect a highly hydrophobic core inducing a conformational change impacting in RBD interaction and could give reason for a higher affinity for the 2019-nCov spike protein All rights reserved. No reus.....
Document: We integrated genomic data from 5 Italian centers (Siena, Naple, Turin, Bologna Along with these more common variants we also identified very rare variants, some of which only described in the non-Finnish European population. Some of them are able to affect a highly hydrophobic core inducing a conformational change impacting in RBD interaction and could give reason for a higher affinity for the 2019-nCov spike protein All rights reserved. No reuse allowed without permission. author/funder, who has granted medRxiv a license to display the preprint in perpetuity.
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