Author: Duque, MarÃa D.; Camps, Pelayo; Profire, Lenuta; Montaner, Silvia; Vázquez, Santiago; Sureda, Francesc X.; Mallol, Jordi; López-Querol, Marta; Naesens, Lieve; Clercq, Erik De; Prathalingam, S. Radhika; Kelly, John M.
Title: Synthesis and pharmacological evaluation of (2-oxaadamant-1-yl)amines Cord-id: x7s1f9gd Document date: 2009_4_1
ID: x7s1f9gd
Snippet: The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
Document: The synthesis of several (2-oxaadamant-1-yl)amines is reported. They were evaluated as NMDA receptor antagonists and several of them were more active than amantadine, but none was more potent than memantine. None of the tested compounds displayed antiviral activity. Two of the derivatives showed a significant level of trypanocidal activity.
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